July 19, 2013: ALERTT Working Group Article on Definitions of Misuse, Abuse, and Related Events Published in Pain
The following article, prepared by the ACTTION Abuse Liability Evaluation for Research, Treatment, and Training (ALERTT) Working Group, has recently been published electronically in Pain. On the basis of a comprehensive systematic review and a consensus meeting, the working group developed mutually exclusive classifications and definitions of misuse, abuse, and related events to increase accuracy and consistency in characterizing their occurrence and prevalence in clinical trials of analgesic medications.
Smith SM, Dart RC, Katz NP, Paillard F, Adams EH, Comer SD, Degroot A, Edwards RR, Haddox JD, Jaffe JH, Jones CM, Kleber HD, Kopecky EA, Markman JD, Montoya ID, O'Brien C, Roland CL, Stanton M, Strain EC, Vorsanger G, Wasan AD, Weiss RD, Turk DC, Dworkin RH. Classification and definition of misuse, abuse, and related events in clinical trials: ACTTION systematic review and recommendations. Pain, 2013;154:2287-2296.
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ACTTION Guide to Clinical Trials of Pain Treatments
The ACTTION Guide to Clinical Trials of Pain Treatments consists of two supplements published in the journal Pain Reports that include a series of articles describing research designs and methods, study conduct, outcome measures, data analyses and interpretation, and reporting recommendations for clinical trials of acute and chronic pain treatments.
Part I includes 9 articles that can be found here, and Part II includes 6 articles that can be found here.