February 5, 2014: Drs. Rice and Dworkin Authors of Article in the Lancet
Dr. Andrew Rice, Europain liaison to ACTTION, and Dr. Robert Dworkin, Director of ACTTION, have authored an article published in the Lancet describing the results of a placebo-controlled, double-blind randomized phase 2 clinical trial in patients with postherpetic neuralgia. The results of the trial showed that patients administered an angiotensin II type 2 receptor antagonist reported significantly less pain than patients who received placebo in the final week of a 28-day treatment period. The article was highlighted by the journal as an "Editor's Choice," and as noted in an accompanying Commentary by Drs. Nanna Finnerup and Cathrine Baastrup, the trial included several novel methodologic features recommended in recent IMMPACT publications on increasing assay sensitivity in analgesic trials.
Rice ASC, Dworkin RH, McCarthy TD, Anand P, Bountra C, McCloud PI, Hill J, Cutter G, Kitson G, Desem N, Raff M. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial. Lancet, early online publication, 5 February 2014. doi:10.1016/S0140-6736(13)62337-5http://www.thelancet.com/images/clear.gif.
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ACTTION Guide to Clinical Trials of Pain Treatments
The ACTTION Guide to Clinical Trials of Pain Treatments consists of two supplements published in the journal Pain Reports that include a series of articles describing research designs and methods, study conduct, outcome measures, data analyses and interpretation, and reporting recommendations for clinical trials of acute and chronic pain treatments.
Part I includes 9 articles that can be found here, and Part II includes 6 articles that can be found here.