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July 19, 2013: ALERTT Working Group Article on Definitions of Misuse, Abuse, and Related Events Published in Pain


The following article, prepared by the ACTTION Abuse Liability Evaluation for Research, Treatment, and Training (ALERTT) Working Group, has recently been published electronically in Pain. On the basis of a comprehensive systematic review and a consensus meeting, the working group developed mutually exclusive classifications and definitions of misuse, abuse, and related events to increase accuracy and consistency in characterizing their occurrence and prevalence in clinical trials of analgesic medications.

Smith SM, Dart RC, Katz NP, Paillard F, Adams EH, Comer SD, Degroot A, Edwards RR, Haddox JD, Jaffe JH, Jones CM, Kleber HD, Kopecky EA, Markman JD, Montoya ID, O'Brien C, Roland CL, Stanton M, Strain EC, Vorsanger G, Wasan AD, Weiss RD, Turk DC, Dworkin RH. Classification and definition of misuse, abuse, and related events in clinical trials: ACTTION systematic review and recommendations. Pain, 2013;154:2287-2296.